The Prevalence of Intraocular Tuberculosis in HIV-positive and HIV-negative Patients in South Africa Using a Revised Classification System

Ocul Immunol Inflamm. 2018;26(6):830-837. doi: 10.1080/09273948.2016.1263342. Epub 2016 Dec 23.


Purpose: To report the prevalence of intraocular tuberculosis in South Africa using a revised classification system.

Methods: A prospective study to determine the underlying etiology in patients presenting with uveitis to a tertiary Eye Clinic.

Results: A total of 35 out of 106 patients (33.0%) were diagnosed with intraocular tuberculosis, of which 11 (31.4%) had HIV infection; 23 patients (65.7%) had possible intraocular tuberculosis and 12 (34.3%) had probable intraocular tuberculosis. Patients with probable intraocular tuberculosis were younger than those with possible intraocular tuberculosis (p = 0.003). More males (66.7%) had probable intraocular tuberculosis and more females (73.9%) had possible intraocular tuberculosis (p = 0.031). More HIV-positive patients had probable intraocular tuberculosis and more HIV-negative patients had possible intraocular tuberculosis (p = 0.002).

Conclusions: South Africa has a high prevalence of intraocular tuberculosis. Younger, male, HIV-positive patients are more likely to have probable intraocular tuberculosis, while older, female, HIV-negative patients are more likely to have possible intraocular tuberculosis.

Keywords: Classification; HIV; South Africa; intraocular tuberculosis; prevalence.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • HIV Seronegativity*
  • HIV Seropositivity*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • South Africa / epidemiology
  • Tuberculosis, Ocular / classification
  • Tuberculosis, Ocular / epidemiology*
  • Young Adult