Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Combination Treatment in Patients with HIV/HCV Co-Infection: Results of an Italian Compassionate Use Program

Andreoni Massimo; Elisabetta Teti; Andrea Antinori; Laura Milazzoi; Savatore Sollima; Giuliano Rizzardini; Antonio Di Biagio; Annalisa Saracino; Raffaele Bruno; Vanni Borghi; Andrea De Luca; Annamaria Cattelan; Hamid Hasson; Gloria Taliani; Antonella D'Arminio Monforte; Claudio Maria Mastroianni; Giovanni Di Perri; Sara Bigoni; Massimo Puoti; Angiola Spinetti; Andrea Gori; Nicola Boffa; Cacopardo Bruno; Andrea Giacometti; Giustino Parruti; Vincenzo Vullo; Antonio Chirianni; Alfredo Pennica; Caterina Pasquazzi; Daniela Segala; Loredana Sarmati; SIMIT (Società Italiana di Malattie Infettivee Tropicali)

doi:10.1093/cid/ciw846

Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Combination Treatment in Patients with HIV/HCV Co-Infection: Results of an Italian Compassionate Use Program

Clin Infect Dis. 2017 Mar 1;64(5):680-683. doi: 10.1093/cid/ciw846. Epub 2016 Dec 22.

Authors

Andreoni Massimo¹, Elisabetta Teti¹, Andrea Antinori², Laura Milazzoi³, Savatore Sollima³, Giuliano Rizzardini⁴, Antonio Di Biagio⁵, Annalisa Saracino⁶, Raffaele Bruno⁷, Vanni Borghi⁸, Andrea De Luca⁹, Annamaria Cattelan¹⁰, Hamid Hasson¹¹, Gloria Taliani¹², Antonella D'Arminio Monforte¹³, Claudio Maria Mastroianni¹⁴, Giovanni Di Perri¹⁵, Sara Bigoni¹⁶, Massimo Puoti¹⁷, Angiola Spinetti¹⁸, Andrea Gori¹⁹, Nicola Boffa²⁰, Cacopardo Bruno²¹, Andrea Giacometti²², Giustino Parruti²³, Vincenzo Vullo²⁴, Antonio Chirianni²⁵, Alfredo Pennica²⁶, Caterina Pasquazzi²⁶, Daniela Segala²⁷, Loredana Sarmati¹; SIMIT (Società Italiana di Malattie Infettivee Tropicali)

Affiliations

¹ Clinical Infectious Diseases, Department. of Systems Medicine, Tor Vergata University, Rome, Italy.
² Clinical Department, National Institute for Infectious Diseases, INMI "L. Spallanzani″, Rome, Italy.
³ Department of Biomedical and Clinical Science, University of Milan,Milan, Italy.
⁴ Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy, and School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Infectious Disease Clinic, IRCCS University Hospital, San Martino IST, Genova, Italy.
⁶ Institute of Infectious Disease, University of Bari, Bari, Italy.
⁷ Division of Infectious and Tropical Diseases, IRCCS Policlinico San Matteo, Pavia, Italy.
⁸ Infectious Diseases Clinic, University Hospital, Modena, Italy.
⁹ Department of Internal and Specialty Medicine University Infectious Diseases Unit, AOU Senese, Siena, Italy.
¹⁰ Department of Infectious and Tropical Diseases, University Hospital, Padova, Italy.
¹¹ Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
¹² Department of Clinical Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
¹³ Clinic of Infectious and Tropical Diseases, Department of Health Sciences, University of Milan, Milan, Italy.
¹⁴ Infectious Diseases Unit, Sapienza University of Rome, Latina, Italy, and Department of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
¹⁵ Unit of Infectious Diseases, University of Turin, Department of Medical Sciences, "Amedeo di Savoia″ Hospital, Turin, Italy.
¹⁶ Division of Infectious Diseases, AO Papa Giovanni XXIII, Bergamo, Italy.
¹⁷ Division of Infectious Diseases, AO Niguarda Ca' Granda Hospital, Milan, Italy.
¹⁸ Division of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
¹⁹ Division of Infectious Diseases, Department of Internal Medicine, "San Gerardo″ Hospital, University of Milan-Bicocca, Milan, Italy.
²⁰ First Division of Infectious Diseases, S. Giovanni di Dio e Ruggi d'Aragona Hospital, Salerno, Italy.
²¹ Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.
²² Infectious Diseases Unit, Department of Biomedical Sciences and Public Health, Marche Polytechnic University c/o Ospedali Riuniti, Ancona, Italy.
²³ Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.
²⁴ Department of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
²⁵ III U.O.C. P.O. Cotugno, AORN Ospedali dei Colli, Naples, Italy.
²⁶ Clinical Infectious Diseases, Sant'Andrea Hospital - Sapienza University of Rome, Rome, Italy.
²⁷ Unit of Infectious Diseases, University Hospital of Ferrara, Ferrara, Italy.

PMID: 28011605
DOI: 10.1093/cid/ciw846

Abstract

Patients co-infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are at high risk of liver disease progression. We report a favorable safety profile and SVR12 rates of 96.7% among HIV/HCV co-infected patients participating in an Italian compassionate-use program of ombitasvir/paritaprevir/ritonavir + dasabuvir (OBV/PTV/r + DSV) ± ribavirin (RBV).

Keywords: DAA; HIV/HCV co-infection; IFN-free; anti-HCV therapy; antiviral therapy.