Posner-Schlossman syndrome

Surv Ophthalmol. 2017 May-Jun;62(3):277-285. doi: 10.1016/j.survophthal.2016.12.005. Epub 2016 Dec 22.


Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of nongranulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males. Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Successful disease management is often achieved by topical treatment, although systemic therapy and even surgical intervention may be required. We discuss our current understanding of Posner-Schlossman syndrome, from its pathophysiology through to recommended treatment options.

Keywords: Posner-Schlossman; cytomegalovirus; glaucoma; glaucomacyclitic crisis; iridocyclitis; uveitis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Management*
  • Glaucoma, Open-Angle* / complications
  • Glaucoma, Open-Angle* / diagnosis
  • Glaucoma, Open-Angle* / therapy
  • Humans
  • Intraocular Pressure*
  • Iridocyclitis* / complications
  • Iridocyclitis* / diagnosis
  • Iridocyclitis* / therapy
  • Syndrome