The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats

Agents Actions. 1989 Jun;27(3-4):344-6. doi: 10.1007/BF01972818.


The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were treated for 18 days with CSA (100% at 10 mg/kg) or MTX (100% at 0.1 mg/kg). Body weights of drug treated AA rats were increased above untreated AA rats and were similar to non-arthritic controls. AA rats show elevated T helper (W3/25+)/T suppressor (OX 8+) cell ratios (2.0 vs. 3.1, p less than 0.01). The immunomodulators tested all returned these elevated ratios to control non-arthritic levels. Similarly, these drugs returned the reduced mitogen responses and elevated blood granulocyte numbers toward normal non-arthritic control values.

MeSH terms

  • Animals
  • Arthritis
  • Arthritis, Experimental / drug therapy*
  • Arthritis, Experimental / pathology
  • Arthritis, Experimental / physiopathology
  • Cyclosporins / therapeutic use
  • Foot / pathology
  • Immunosuppressive Agents / therapeutic use*
  • Indomethacin / therapeutic use
  • Male
  • Methotrexate / therapeutic use
  • Rats
  • Rats, Inbred Strains
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / metabolism


  • Cyclosporins
  • Immunosuppressive Agents
  • Indomethacin
  • Methotrexate