Biomarkers Associated With Sedentary Behaviour in Older Adults: A Systematic Review

Ageing Res Rev. 2017 May;35:87-111. doi: 10.1016/j.arr.2016.12.002. Epub 2016 Dec 23.

Abstract

Objective: Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.

Methods: Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60years and accelerometer wear time ≥3days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).

Results: 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n=15), waist circumference (WC, n=15), blood pressure (n=11), triglycerides (n=12) and high density lipoprotein (HDL, n=15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.

Conclusion: Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

Keywords: Biomarker; Older adults; Sedentary behaviour.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / blood
  • Body Mass Index*
  • Cardiovascular Diseases* / diagnosis
  • Cardiovascular Diseases* / epidemiology
  • Cardiovascular Diseases* / metabolism
  • Cholesterol / blood*
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Insulin / blood*
  • Middle Aged
  • Risk Factors
  • Sedentary Behavior*
  • Statistics as Topic

Substances

  • Biomarkers
  • Glycated Hemoglobin A
  • Insulin
  • Cholesterol