Dynamic chromatin regulation at Notch target genes

Transcription. 2017 Jan;8(1):61-66. doi: 10.1080/21541264.2016.1265702. Epub 2016 Dec 27.


RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.

Keywords: KMT2D; NCoR; NICD; Notch; RBPJ; SHARP; casein kinase 2; chromatin; transcription; transcriptional activation; transcriptional repression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Chromatin / metabolism*
  • Gene Expression Regulation*
  • Gene Regulatory Networks
  • Histones / chemistry
  • Humans
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism*
  • Methylation
  • Multiprotein Complexes / metabolism
  • Phosphorylation
  • Protein Binding
  • Receptors, Notch / metabolism*
  • Transcription, Genetic


  • Chromatin
  • Histones
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein
  • Multiprotein Complexes
  • Receptors, Notch