Reduced islet function contributes to impaired glucose homeostasis in fructose-fed mice

Am J Physiol Endocrinol Metab. 2017 Feb 1;312(2):E109-E116. doi: 10.1152/ajpendo.00279.2016. Epub 2016 Dec 27.


Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. Therefore, we examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance but not hyperinsulinemia, dyslipidemia, or hyperuricemia. Islet function was impaired, with decreased glucose-stimulated insulin secretion and increased glucagon secretion and high fructose consumption leading to α-cell proliferation and upregulation of the fructose transporter GLUT5, which was localized only in α-cells. Our studies demonstrate that excess fructose consumption contributes to hyperglycemia by affecting both β- and α-cells of islets in mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Dietary Carbohydrates / pharmacology
  • Down-Regulation / drug effects
  • Fructose / pharmacology*
  • Glucose / metabolism*
  • Glucose Intolerance / metabolism
  • Homeostasis / drug effects*
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / physiology*
  • Male
  • Mice
  • Mice, Inbred C57BL


  • Dietary Carbohydrates
  • Fructose
  • Glucose