Thrombocytopenia associated with heparin-coated catheters in patients with heparin-associated antiplatelet antibodies

Arch Intern Med. 1989 Oct;149(10):2285-7.


Thrombocytopenia was associated with the presence of heparin-coated pulmonary artery catheters in 12 patients with heparin-associated antiplatelet antibodies. The thrombocytopenia persisted so long as the heparin-coated catheters were in place, even when all other sources of heparin were discontinued. The high morbidity and mortality associated with heparin-induced thrombocytopenia mandates that heparin administration cease and that all heparin-coated catheters be removed from patients with heparin-associated antiplatelet antibodies.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies / immunology*
  • Blood Platelets / immunology*
  • Catheterization, Central Venous / adverse effects
  • Catheters, Indwelling / adverse effects*
  • Female
  • Heparin / adverse effects*
  • Heparin / immunology
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation / drug effects
  • Platelet Count / drug effects
  • Pulmonary Artery
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / immunology


  • Antibodies
  • Heparin