1. Beriplast P was used in 48 places, at 36 neurosurgical operations in 34 patients for various purposes. 2. No complications were encountered. Its use proved useful for sealing an inadvertently entered paranasal sinuses and as an auxiliary measure of controlling venous bleeding from dural sinuses or dural venous lakes difficult to control by usual means. 3. As to its use for sealing the site of dural closure to prevent the leakage and accumulation of the cerebrospinal fluid, it proved useful in the selected patients, but it should be emphasized that the meticulous closure with surgical sutures is of utmost importance and that the availability of fibrin glue does never replace the skillful operative techniques. 4. A case where Beriplast P applied over the dural surface caused obstruction of an epidural drain and resultant epidural hematoma was presented.