Oligodendroglial cell proliferation arising in an ovarian mature cystic teratoma. Clinicopathological, inmunohistochemical, and ultrastructural study of a case that may represent an oligodendroglioma

Ultrastruct Pathol. 2017 Jan-Feb;41(1):62-66. doi: 10.1080/01913123.2016.1261975. Epub 2016 Dec 28.


Ovarian mature cystic teratoma (OMCT) is an ovarian benign neoplasm with excellent prognosis presenting components of the three germinal layers. However, transformation into a malignant neoplasm is a rare event (so-called somatic transformation). In most of the cases, the malignant component expresses as epidermoid carcinoma, but occasionally central nervous system tumors occur. Some of the previously reported tumors are astrocytoma, glioblastoma, and ependymoma. Somatic transformation of OMCT into an oligodendroglioma is exceptional. We report a 19-year-old female with a left OMCT with an area of oligonedroglial cells proliferation characterized by immunohistochemical studies with positivity for GFAP and S100, with a low Ki67 index (5%). Additionally, electron microscopy revealed oligodendrocytes with parallel bundles of cytoplasmic intermediate filaments, confirming the oligodendroglial nature of the proliferation. The patient was treated only with left oophorectomy, and three and half years after surgery, there is no evidence of disease.

Keywords: Oligodendroglioma; ovary; teratoma; ultrastructure.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Cell Proliferation*
  • Female
  • Humans
  • Immunohistochemistry*
  • Microscopy, Electron*
  • Neoplasms, Cystic, Mucinous, and Serous / chemistry
  • Neoplasms, Cystic, Mucinous, and Serous / diagnosis*
  • Neoplasms, Cystic, Mucinous, and Serous / surgery
  • Neoplasms, Cystic, Mucinous, and Serous / ultrastructure
  • Oligodendroglioma / chemistry
  • Oligodendroglioma / diagnosis*
  • Oligodendroglioma / surgery
  • Oligodendroglioma / ultrastructure
  • Ovarian Neoplasms / chemistry
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / surgery
  • Ovarian Neoplasms / ultrastructure
  • Ovariectomy
  • Predictive Value of Tests
  • Salpingectomy
  • Teratoma / chemistry
  • Teratoma / diagnosis*
  • Teratoma / surgery
  • Teratoma / ultrastructure
  • Treatment Outcome
  • Young Adult


  • Biomarkers, Tumor

Supplementary concepts

  • Teratoma, Ovarian