Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients

Pediatr Infect Dis J. 2017 Jun;36(6):618-620. doi: 10.1097/INF.0000000000001519.

Abstract

We report an unusual cluster of invasive group A Streptococcus infections in 6 pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of group A Streptococcus genotypes and helped guide our institutional response and public health maneuvers.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / microbiology*
  • Child
  • Child, Preschool
  • DNA, Bacterial / analysis*
  • DNA, Bacterial / genetics
  • Female
  • Genome, Bacterial / genetics*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Sequence Analysis, DNA
  • Streptococcal Infections / microbiology*
  • Streptococcus pyogenes / drug effects
  • Streptococcus pyogenes / genetics*
  • Streptococcus pyogenes / pathogenicity

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial