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, 6 (6), 559-567

The Efficiency of Child Formula Dentifrices Containing Different Calcium and Phosphate Compounds on Artificial Enamel Caries

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The Efficiency of Child Formula Dentifrices Containing Different Calcium and Phosphate Compounds on Artificial Enamel Caries

Praphasri Rirattanapong et al. J Int Soc Prev Community Dent.

Abstract

Objectives: Fluoride toothpaste has been extensively used to prevent dental caries. However, the risk of fluorosis is concerning, especially in young children. Calcium phosphate has been an effective remineralizing agent and is present in commercial dental products, with no risk of fluorosis to users. This in vitro study aimed to compare the effects of different calcium phosphate compounds and fluoride-containing dentifrices on artificial caries in primary teeth.

Materials and methods: Fifty sound primary incisors were coated with nail varnish, leaving two 1 mm2 windows on the labial surface before immersion in demineralizing solution for 96 hours to produce artificial enamel lesions. Subsequently, one window from each tooth was coated with nail varnish, and all 50 teeth were divided into five groups (n = 10); group A - deionized water; group B - casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste (Tooth Mousse); group C - 500 ppm F (Colgate Spiderman®); group D - nonfluoridated toothpaste with triple calcium phosphate (Pureen®); and group E - tricalcium phosphate (TCP). Polarized light microscopy and Image-Pro® Plus software were used to evaluate lesions.

Results: After a 7-day pH-cycle, mean lesion depths in groups A, B, C, D, and E had increased by 57.52 ± 10.66%, 33.28 ± 10.16%, 17.04 ± 4.76%, 32.51 ± 8.99%, and 21.76 ± 8.15%, respectively. All data were processed by the Statistical Package for the Social Sciences (version 16.0) software package. Comparison of percentage changes using one-way analysis of variance and Fisher's least squares difference tests at a 95% level of confidence demonstrated that group A was significantly different from the other groups (P < 0.001). Lesions in groups B and D had a significant lesion progression when compared with groups C and E.

Conclusions: All toothpastes in this study had the potential to delay the demineralization progression of artificial enamel caries in primary teeth. The fluoride 500 ppm and TCP toothpastes were equal in the deceleration of enamel caries progression and better than CPP-ACP paste and TCP toothpaste.

Keywords: Artificial caries; calcium lactate; casein phosphopeptide-amorphous calcium phosphate; dicalcium phosphate dihydrate; primary teeth; toothpaste; tricalcium phosphate.

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Graph showed the mean lesion depth in all treatment groups before and after a 7-day pH-cycling process
Figure 2
Figure 2
Graph showed the percentage change of mean lesion depths in all treatment groups before and after a 7-day pH-cycling process
Figure 3
Figure 3
Polarized light photomicrograph of enamel lesion after treatment in Group A (deionized water)
Figure 4
Figure 4
Polarized light photomicrograph of enamel lesion after treatment in Group B (CPP-ACP paste)
Figure 5
Figure 5
Polarized light photomicrograph of enamel lesion after treatment in Group C (500 ppm F dentifrice)
Figure 6
Figure 6
Polarized light photomicrograph of enamel lesion after treatment in Group D (triple calcium phosphate dentifrice)
Figure 7
Figure 7
Polarized light photomicrograph of enamel lesion after treatment in Group E (TCP dentifrice)

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References

    1. Marinho VC, Higgins JP, Logan S, Sheiham A. Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2003:CD002782. - PMC - PubMed
    1. Twetman S, Axelsson S, Dahlgren H, Holm AK, Kallestal C, Lagerlof F, et al. Caries-preventive effect of fluoride toothpaste: A systematic review. Acta Odontol Scand. 2003;61:347–55. - PubMed
    1. Do LG, Spencer AJ. Risk-benefit balance in the use of fluoride among young children. J Dent Res. 2007;86:723–8. - PubMed
    1. Evans RW, Dennison PJ. The Caries Management System: An evidence-based preventive strategy for dental practitioners. Application for children and adolescents. Aust Dent J. 2009;54:381–9. - PubMed
    1. European Academy of Paediatric Dentistry. Guidelines on the use of fluoride in children: An EAPD policy document. Eur Arch Paediatr Dent. 2009;10:129–35. - PubMed
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