Reversible RNA modifications in meiosis and pluripotency

Nat Methods. 2016 Dec 29;14(1):18-22. doi: 10.1038/nmeth.4111.


Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epigenesis, Genetic / genetics*
  • Humans
  • Meiosis / genetics*
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*
  • RNA / chemistry*
  • RNA / genetics*


  • RNA