Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice

Edward O List; Elizabeth Jensen; Jesse Kowalski; Mathew Buchman; Darlene E Berryman; John J Kopchick

doi:10.3233/NHA-1614

Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice

Nutr Healthy Aging. 2016 Oct 27;4(1):95-99. doi: 10.3233/NHA-1614.

Authors

Edward O List¹, Elizabeth Jensen², Jesse Kowalski², Mathew Buchman², Darlene E Berryman³, John J Kopchick³

Affiliations

¹ Edison Biotechnology, Ohio University, Athens, OH, USA; Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA.
² Edison Biotechnology, Ohio University , Athens, OH, USA.
³ Edison Biotechnology, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.

Abstract

Previously, our laboratory reported that weight-cycled mice outlive their obese counterparts. To gain a better mechanistic understanding of these results, we evaluated cellular senescence in white adipose tissue (WAT) of lean, obese, and weight cycled mice. Our results show that at the end of a 28 day weight loss cycle cellular senescence is significantly reduced in multiple WAT depots compared to obese mice, which also corresponds to a reduction in circulating activin A (a marker of senescence). These findings suggest that a previously undescribed benefit to weight loss may be a reduction of cellular senescence in WAT.

Keywords: White adipose tissue; activin A; cellular senescence; obesity; weight cycling; weight loss; yo-yo diet.