Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore

Int Ophthalmol. 2018 Feb;38(1):11-18. doi: 10.1007/s10792-016-0401-6. Epub 2016 Dec 29.

Abstract

Aim: To report the clinical features and outcome of patients with presumed tubercular uveitis (TBU).

Methods: Retrospective analysis of patients with presumed TBU at a tertiary referral eye care centre in Singapore between 2007 and 2012 was done. Main outcome measures were failure of complete resolution of uveitis or recurrence of inflammation.

Results: Fifty three patients with mean age of 44.18 ± 15.26 years with 54.72% being males were included. 19 (35.85%) had bilateral involvement, with panuveitis and anterior uveitis being the most common presentations. 36 (67.92%) patients received antitubercular therapy (ATT), and 28 received concurrent systemic steroids. 15 (28.30%) eyes of 11 (30.55%) patients in the ATT group and 4 (21.05%) eyes of 3 (17.64%) patients in the non-ATT group had treatment failure (p value = 0.51).

Conclusion: The use of ATT, with or without concurrent corticosteroid, may not have a statistically significant impact in improving treatment success in patients with presumed TBU.

Keywords: Antitubercular therapy; Panuveitis; Steroids; Tubercular uveitis; Tuberculosis.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / therapeutic use*
  • Child
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Panuveitis / drug therapy
  • Recurrence
  • Retrospective Studies
  • Singapore
  • Tertiary Care Centers / statistics & numerical data
  • Treatment Outcome
  • Tuberculosis, Ocular / drug therapy*
  • Uveitis / drug therapy*
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Antitubercular Agents