Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Yuanchen Dong; Yuhe Renee Yang; Yiyang Zhang; Dianming Wang; Xixi Wei; Saswata Banerjee; Yan Liu; Zhongqiang Yang; Hao Yan; Dongsheng Liu

doi:10.1002/anie.201610133

Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Angew Chem Int Ed Engl. 2017 Feb 1;56(6):1586-1589. doi: 10.1002/anie.201610133. Epub 2016 Dec 30.

Authors

Affiliations

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
² School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

PMID: 28035787
DOI: 10.1002/anie.201610133

Abstract

We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.

Keywords: DNA nanotechnology; amphiphiles; frame-guided assembly; self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Hydrophobic and Hydrophilic Interactions
Nanocapsules / chemistry*
Nanocapsules / ultrastructure
Nanostructures / chemistry*
Nanostructures / ultrastructure
Nanotechnology / methods*
Nucleic Acid Conformation
Surface-Active Agents / chemistry*

Substances

Nanocapsules
Surface-Active Agents
DNA