PBIT: Pipeline Builder for Identification of drug Targets for infectious diseases

Bioinformatics. 2017 Mar 15;33(6):929-931. doi: 10.1093/bioinformatics/btw760.

Abstract

Summary: PBIT (Pipeline Builder for Identification of drug Targets) is an online webserver that has been developed for screening of microbial proteomes for critical features of human drug targets such as being non-homologous to human proteome as well as the human gut microbiota, essential for the pathogen's survival, participation in pathogen-specific pathways etc. The tool has been validated by analyzing 57 putative targets of Candida albicans documented in literature. PBIT integrates various in silico approaches known for drug target identification and will facilitate high-throughput prediction of drug targets for infectious diseases, including multi-pathogenic infections.

Availability and implementation: PBIT is freely accessible at http://www.pbit.bicnirrh.res.in/ .

Contact: thomass@nirrh.res.in.

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Candida albicans / drug effects
  • Candida albicans / metabolism
  • Communicable Diseases / drug therapy*
  • Communicable Diseases / microbiology
  • Computational Biology / methods
  • Computer Simulation*
  • Drug Discovery / methods*
  • Humans
  • Internet
  • Microbiota / drug effects*
  • Proteome / drug effects*

Substances

  • Proteome