[Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein]

Alice Prigent; Arthur Lionnet; Anne-Gaëlle Corbillé; Pascal Derkinderen

doi:10.1016/j.lpm.2016.11.010

[Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein]

Presse Med. 2017 Mar;46(2 Pt 1):182-186. doi: 10.1016/j.lpm.2016.11.010. Epub 2016 Dec 28.

[Article in French]

Authors

Alice Prigent¹, Arthur Lionnet², Anne-Gaëlle Corbillé³, Pascal Derkinderen⁴

Affiliations

¹ Inserm, U913, 44035 Nantes, France.
² CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France.
³ Inserm, U913, 44035 Nantes, France; CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France; Université de Nantes, 44035 Nantes, France.
⁴ Inserm, U913, 44035 Nantes, France; CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France; Université de Nantes, 44035 Nantes, France. Electronic address: derkinderenp@yahoo.fr.

PMID: 28040347
DOI: 10.1016/j.lpm.2016.11.010

Abstract

The past 20 years has witnessed tremendous progress in our understanding of Parkinson's disease. It is now well established that α-synuclein, a presynaptic neuronal protein, is not only a marker but also an actor of the disease. In this review, we discuss the advances that have been obtained in neuropathology using α-synuclein immunohistochemistry and the role of this protein in the spread of the disease.

MeSH terms

Brain Chemistry
Enteric Nervous System / metabolism
Enteric Nervous System / physiopathology
Humans
Immunohistochemistry
Lewy Bodies / chemistry
Models, Neurological
Nervous System / metabolism
Nervous System / physiopathology*
Neurons / metabolism
Organ Specificity
Oxidative Stress
Parkinson Disease / genetics
Parkinson Disease / physiopathology*
Phosphorylation
Protein Processing, Post-Translational
Spinal Cord Dorsal Horn / metabolism
Spinal Cord Dorsal Horn / physiopathology
Vagus Nerve / metabolism
Vagus Nerve / physiopathology
alpha-Synuclein / deficiency
alpha-Synuclein / genetics
alpha-Synuclein / physiology*

Substances

alpha-Synuclein