The effects of vitamin B on the immune/cytokine network and their involvement in depression

Maturitas. 2017 Feb;96:58-71. doi: 10.1016/j.maturitas.2016.11.012. Epub 2016 Nov 19.


Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

Keywords: Depression; Immune cells; Immune system; Inflammation; Mental health.

Publication types

  • Review

MeSH terms

  • Cytokines / immunology*
  • Depression / immunology*
  • Humans
  • Immune System*
  • Interleukin-1 / immunology
  • Interleukin-6 / immunology
  • Tumor Necrosis Factor-alpha / immunology
  • Vitamin B Complex / immunology*
  • Vitamin B Deficiency / complications*


  • Cytokines
  • Interleukin-1
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Vitamin B Complex