Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate

K V Kovtunov; D A Barskiy; O G Salnikov; R V Shchepin; A M Coffey; L M Kovtunova; V I Bukhtiyarov; I V Koptyug; E Y Chekmenev

doi:10.1039/C6RA15808K

Toward Production of Pure ¹³C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-¹³C]acetate

RSC Adv. 2016;6(74):69728-69732. doi: 10.1039/C6RA15808K. Epub 2016 Jul 15.

Authors

K V Kovtunov¹, D A Barskiy², O G Salnikov¹, R V Shchepin², A M Coffey², L M Kovtunova³, V I Bukhtiyarov³, I V Koptyug¹, E Y Chekmenev⁴

Affiliations

¹ Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
² Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA.
³ Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia; Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090 Russia.
⁴ Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA; Russian Academy of Sciences, Leninskiy Prospect 14, 119991 Moscow, Russia.

Abstract

Here, we report the production of ¹³C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO₂-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of ¹³C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.

Abstract

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