[Limitation of ischemic necrosis by the use of antioxidant ionol]

Biull Eksp Biol Med. 1989 Aug;108(8):152-4.
[Article in Russian]


Inhibitory effect of Ionol on lipid peroxidation (LPO) in the infarction zone and out of it after experimental myocardial infarction in the experiments on rats was investigated. The results of measurements, performed by two independent methods: point counting and the computer image analysis were compared. It was shown that LPO activation out of the ischaemic zone was prevented and dimensions of the ischaemic necrosis were limited by Ionol, which did not influence LPO activation in the ischaemic zone. Data obtained by both methods coincide qualitatively, the computer image analysis being more sensitive and effective.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Administration, Oral
  • Animals
  • Butylated Hydroxytoluene / administration & dosage
  • Butylated Hydroxytoluene / pharmacology*
  • Catalase / analysis
  • Glutathione Peroxidase / analysis
  • Image Processing, Computer-Assisted
  • Lipid Peroxidation / drug effects
  • Male
  • Models, Biological
  • Myocardial Infarction / pathology*
  • Myocardium / enzymology
  • Myocardium / pathology*
  • Necrosis
  • Rats


  • Butylated Hydroxytoluene
  • Catalase
  • Glutathione Peroxidase