Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles

Org Lett. 2017 Jan 20;19(2):308-311. doi: 10.1021/acs.orglett.6b03295. Epub 2017 Jan 3.

Abstract

A highly efficient palladium-catalyzed intramolecular aminoalkylation of unactivated alkenes in the absence of an external ligand and oxidant is described. New C-N and C(sp3)-C(sp3) bonds are formed simultaneously. This general transformation allows for construction of diverse N-heterocycles. Mechanistic studies show that the process may involve a four-membered Pd(alkyl)amido intermediate.

Publication types

  • Research Support, Non-U.S. Gov't