Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman

Mucosal Immunol. 2017 Jul;10(4):884-886. doi: 10.1038/mi.2016.117. Epub 2017 Jan 4.


Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of the intestine sensitizing them to NAD-induced cell death (NICD); thus, demonstrating a previously unrecognized role of RA in effector T-cell contraction.

Publication types

  • Comment

MeSH terms

  • Receptors, Purinergic
  • T-Lymphocytes*
  • Tretinoin*


  • Receptors, Purinergic
  • Tretinoin