Spondylocostal dysostosis: an example of autosomal dominant transmission in a large family

Clin Genet. 1989 Oct;36(4):236-41. doi: 10.1111/j.1399-0004.1989.tb03196.x.


This report gives a description of a three-generation family in which spondylocostal dysostosis associated with previously unreported neurological complaints occurred in five family members, suggesting autosomal dominant inheritance. A review of the literature is presented and previously unreported neurological complaints, e.g. neurogenic claudicatio, are emphasized.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / genetics*
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Pedigree
  • Radiography
  • Ribs / abnormalities*
  • Ribs / diagnostic imaging
  • Syndrome
  • Synostosis / genetics
  • Thoracic Vertebrae / abnormalities*
  • Thoracic Vertebrae / diagnostic imaging