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. 2016 Feb 3;7(1):9-13.
doi: 10.1016/j.jtcme.2015.12.006. eCollection 2017 Jan.

Hepatoprotective Potential of Ethanolic Extract of Aquilaria agallocha Leaves Against Paracetamol Induced Hepatotoxicity in SD Rats

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Free PMC article

Hepatoprotective Potential of Ethanolic Extract of Aquilaria agallocha Leaves Against Paracetamol Induced Hepatotoxicity in SD Rats

Janey Alam et al. J Tradit Complement Med. .
Free PMC article

Abstract

Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of 'ethanolic extract of Aquilaria agallocha ( Chen Xiang) leaves' (AAE) against paracetamol (PCM) induced hepatotoxicity in SD rats. Group I animals were treated with 1% CMC for 8 days. Group II, III, IV and V animals were first treated with '1% CMC' 1 ml/kg/day, AAE 200 mg/kg/day, AAE 400 mg/kg/day and silymarin 100 mg/kg/day respectively for 7 days and then, orally administered with PCM 3 g/kg b. wt. on 8th day in a single dose. 24 h after the last dosing by PCM, the blood was obtained through the retro-orbital plexus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, cholesterol, TP and ALB. Group IV rats showed significant (p < 0.01) decrease in ALT, AST, ALP, LDH, cholesterol, bilirubin, liver wt. and relative liver wt. levels while significant (p < 0.01) increase in final b. wt., TP and ALB levels as compared to group II rats. Hepatoprotective potential of AAE 400 mg/kg/day was comparable to that of standard drug silymarin 100 mg/kg/day. Results of the study were well supported by the histopathological observations. This study confirms that AAE possesses hepatoprotective potential comparable to that of standard drug silymarin as it exhibited comparable protective potential against PCM induced hepatotoxicity in SD rats.

Keywords: Aquilaria agallocha; Hepatoprotective potential; Hepatotoxicity; Oxidative stress; Paracetamol.

Figures

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Fig. 1
Fig. 1
Gross anatomy of liver in control and experimental groups of rats: Group I is with normal appearance. Marks in group (II) indicated damage of liver cells. Marks in rest of the groups (III, IV and V) indicated recovery of damage cells towards normal.
Fig. 2
Fig. 2
Histopathologicy of liver tissues in control and experimental groups of rats. (I) Normal control group: showed the well defined architecture and vesicular nuclei. (II) Hepatotoxic group: showed degenerative changes in hepatocytes and necrosis occurred. (III) Group treated with AAE 200 mg/kg: showed proliferative hepatocytes with mild degenerative changes and increased inter cellular space. (IV) Group treated with AAE 400 mg/kg: showed normal architecture and well defined nuclei when compared with group I. (V) Group treated with silymarin 100 mg/kg: section showed normal architecture with well defined nucleus.

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