Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study

Danni Li; Jeffrey R Misialek; Eric Boerwinkle; Rebecca F Gottesman; A Richey Sharrett; Thomas H Mosley; Josef Coresh; Lisa M Wruck; David S Knopman; Alvaro Alonso

doi:10.1016/j.dadm.2016.09.003

Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study

Alzheimers Dement (Amst). 2016 Nov 1:6:1-10. doi: 10.1016/j.dadm.2016.09.003. eCollection 2017.

Authors

Affiliations

¹ Department of Lab Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
² Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
³ School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
⁴ Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
⁵ School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
⁶ Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
⁷ Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, NC, USA.
⁸ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
⁹ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Abstract

Introduction: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort.

Methods: We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004-2006 and 2011-2013.

Results: After a mean follow-up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow-up visit.

Conclusion: A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.

Keywords: AD; ARIC; ARIC-NCS; Alzheimer's disease; Dementia; MCI; Metabolites; Metabolomics; Mild cognitive impairment; Phospholipids; Plasma.

Abstract

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