Abstract
The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.
Keywords:
APP; Alzheimer's disease; Down syndrome; amyloid; genetics.
© 2017 Federation of European Biochemical Societies.
Publication types
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Historical Article
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Review
MeSH terms
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Alzheimer Disease / diagnosis
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Alzheimer Disease / genetics*
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Alzheimer Disease / history
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Alzheimer Disease / pathology
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Amyloid beta-Protein Precursor / genetics*
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Artifacts
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Chromosomes, Human, Pair 21 / chemistry*
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Down Syndrome / diagnosis
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Down Syndrome / genetics*
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Down Syndrome / history
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Down Syndrome / pathology
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Gene Duplication
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Gene Expression
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Genetic Markers
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History, 20th Century
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Humans
Substances
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APP protein, human
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Amyloid beta-Protein Precursor
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Genetic Markers