Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery

Nutrients. 2017 Jan 4;9(1):29. doi: 10.3390/nu9010029.

Abstract

(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0.01) and oxidative stress (p < 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p < 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.

Keywords: coenzyme Q10; hepatocellular carcinoma; inflammation; oxidative stress; surgery.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aspartate Aminotransferases / blood
  • Blood Glucose / metabolism
  • C-Reactive Protein / metabolism
  • Carcinoma, Hepatocellular / blood*
  • Carcinoma, Hepatocellular / surgery
  • Creatinine / blood
  • Glutathione Peroxidase / blood
  • Humans
  • Inflammation / blood*
  • Interleukin-6 / blood
  • Linear Models
  • Liver Neoplasms / blood*
  • Liver Neoplasms / surgery
  • Malondialdehyde / blood
  • Middle Aged
  • Oxidative Stress*
  • Superoxide Dismutase / blood
  • Thiobarbituric Acid Reactive Substances / analysis
  • Tumor Necrosis Factor-alpha / blood
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Vitamin E / blood
  • Young Adult

Substances

  • Blood Glucose
  • IL6 protein, human
  • Interleukin-6
  • Thiobarbituric Acid Reactive Substances
  • Tumor Necrosis Factor-alpha
  • Ubiquinone
  • Vitamin E
  • Malondialdehyde
  • C-Reactive Protein
  • Creatinine
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Aspartate Aminotransferases
  • coenzyme Q10