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. 2017 Jan 27;80(1):134-140.
doi: 10.1021/acs.jnatprod.6b00758. Epub 2017 Jan 5.

Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum

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Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum

Jun-Pil Jang et al. J Nat Prod. .

Abstract

Two new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single-crystal X-ray diffraction and Marfey's methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 μM.

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