Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis)

Orthop Traumatol Surg Res. 2017 Feb;103(1S):S91-S97. doi: 10.1016/j.otsr.2016.11.002. Epub 2017 Jan 2.


Tenosynovial giant cell tumor (TSGCT) is a rare benign tumor arising from joint synovia, bursae and tendon sheaths. Their variable clinical presentation is related to variations in site and progression. Localized forms are most frequent in the hands, and diffuse forms in the knee. MRI is necessary and sometimes sufficient for diagnosis. Treatment strategy is guided by progression, symptomatology, location and diathesis. Optimally complete resection is the principle of first-line treatment. Radiation therapy is effective and targeted therapies are promising; both should especially be considered in case of relapse.

Keywords: Soft-tissue tumor; Tenosynovial giant cell tumor; Villonodular synovitis.

Publication types

  • Review

MeSH terms

  • Giant Cell Tumor of Tendon Sheath / diagnosis*
  • Giant Cell Tumor of Tendon Sheath / diagnostic imaging
  • Giant Cell Tumor of Tendon Sheath / surgery
  • Hand
  • Humans
  • Knee Joint
  • Magnetic Resonance Imaging
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / surgery