Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease

Drugs. 2017 Feb;77(2):201-208. doi: 10.1007/s40265-016-0681-1.

Abstract

Lifitegrast is a novel small molecule integrin antagonist that blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1). Lifitegrast ophthalmic solution 5% (Xiidra™) was recently approved in the USA for the treatment of dry eye disease. The efficacy of lifitegrast ophthalmic solution 5% was compared with vehicle in a 12-week phase 2 study and three 12-week phase 3 studies (OPUS-1, OPUS-2 and OPUS-3) in patients with dry eye disease. Taken as a whole, results of these trials support the treatment effect of lifitegrast ophthalmic solution 5% in improving a symptom of dry eye disease (i.e. the change from baseline to day 84 in the eye dryness visual analogue scale score) and a sign of dry eye disease (i.e. the change from baseline to day 84 in the inferior corneal fluorescein staining score). Lifitegrast ophthalmic solution 5% was generally well tolerated. In conclusion, lifitegrast ophthalmic solution 5% provides a new option for the treatment of dry eye disease.

Publication types

  • Review

MeSH terms

  • Dry Eye Syndromes / drug therapy*
  • Humans
  • Ophthalmic Solutions / adverse effects
  • Ophthalmic Solutions / chemistry*
  • Ophthalmic Solutions / therapeutic use*
  • Phenylalanine / adverse effects
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / therapeutic use
  • Sulfones / adverse effects
  • Sulfones / therapeutic use*

Substances

  • Ophthalmic Solutions
  • Sulfones
  • lifitegrast
  • Phenylalanine