Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors

Dokl Biochem Biophys. 2016 Nov;471(1):387-389. doi: 10.1134/S160767291606003X. Epub 2017 Jan 6.

Abstract

We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10-6 M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.

MeSH terms

  • Animals
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Agents / administration & dosage*
  • Kainic Acid / administration & dosage
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Patch-Clamp Techniques
  • Peptides, Cyclic / administration & dosage*
  • Peptides, Cyclic / metabolism*
  • Psychotropic Drugs / administration & dosage
  • Purkinje Cells / drug effects*
  • Purkinje Cells / physiology*
  • Rats, Wistar
  • Receptors, AMPA / metabolism*

Substances

  • Excitatory Amino Acid Agents
  • Peptides, Cyclic
  • Psychotropic Drugs
  • Receptors, AMPA
  • cyclo(prolylglycyl)
  • Kainic Acid