Orientation of the Mitotic Spindle in the Development of Tubular Organs

Abstract

Formation of organs that consist primarily or exclusively of tubes is essential for metazoan development. Increasing evidence suggests that the morphogenesis and homeostasis of these tubular organs depend on proper orientation of the mitotic spindle during cell division. Consequently, improper spindle orientation can perturb spatial arrangement of daughter cells, resulting in congenital malformations or dysfunctions of tubular organs. Over the past decade, the association of spindle misorientation with brain diseases and cancer has been extensively studied. However, few studies have explored the effects of spindle misorientation on developmental disorders impacting tubular organs. Here, we examine and interpret recent literature that shows how tubular organ development relies on proper spindle orientation and discuss how defects in this cellular process are associated with the pathogenesis of tubular organ diseases. J. Cell. Biochem. 118: 1630-1633, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: CELL DIVISION; DEVELOPMENT; DISEASE; SPINDLE ORIENTATION; TUBULAR ORGAN.