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. 2017 Jan 27;80(1):190-195.
doi: 10.1021/acs.jnatprod.6b00977. Epub 2017 Jan 6.

α-Glucosidase Inhibitors from Malbranchea flavorosea

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α-Glucosidase Inhibitors from Malbranchea flavorosea

Brisa Verastegui-Omaña et al. J Nat Prod. .

Abstract

From an extract prepared from the grain-based culture of Malbranchea flavorosea two new polyketides, namely, 8-chloroxylarinol A (1) and flavoroseoside (2), along with the known compounds xylarinol A (3), xylarinol B (4), massarigenins B and C (5 and 6), and clavatol (7), were isolated. The structures of 1 and 2 were elucidated using spectroscopic methods and corroborated by single-crystal X-ray diffraction analysis. In the case of compound 2 the absolute configuration at the stereogenic centers was established according to the method of Flack. In addition, the X-ray structure of compound 6 is reported for the first time. Compounds 3, 4, and 6 significantly inhibited yeast α-glucosidase. Compound 6 also inhibited the postprandial peak during an oral sucrose tolerance assay when tested in vivo, using normal and NA/STZ-induced hyperglycemic mice.

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