Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design

Cell Stem Cell. 2017 Jan 5;20(1):13-17. doi: 10.1016/j.stem.2016.12.003.


New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics.

MeSH terms

  • Artificial Cells / cytology*
  • Cell Engineering
  • Cell- and Tissue-Based Therapy / standards*
  • Humans
  • Social Control, Formal
  • Translational Research, Biomedical