Hacking the Matrix

Cell Stem Cell. 2017 Jan 5;20(1):9-10. doi: 10.1016/j.stem.2016.12.010.


Recently in Nature, Gjorevski et al. (2016) describe a fully defined synthetic hydrogel that mimics the extracellular matrix to support in vitro growth of intestinal stem cells and organoids. The hydrogel allows exquisite control over the chemical and physical in vitro niche and enables identification of regulatory properties of the matrix.

Publication types

  • Comment

MeSH terms

  • Extracellular Matrix / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate / analysis*
  • Intestines
  • Organoids*
  • Stem Cells


  • Hydrogel, Polyethylene Glycol Dimethacrylate