Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45

BMC Cardiovasc Disord. 2017 Jan 7;17(1):18. doi: 10.1186/s12872-016-0458-1.


Background: The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend is an important contemporary public health issure.

Methods: A total of 5288 patients (≤45 years) diagnosed with CHD and hospitalized at the Chinese PLA General Hospital and Anzhen Hospital, both in Beijing, were enrolled after satisfying the inclusion criteria.

Results: Young CHD patients increased in number from 2010 to 2014, especially men. Among the studied patients, there was no significant change over those years in blood pressure, but heart rate increased significantly (P < 0.05) and body mass index showed a rising trend (P > 0.05). The incidence of hypertension increased from 40.7 to 47.5%, diabetes from 20.3 to 26.1%, and hyperlipidemia from 27.3 to 35.7% (P < 0.05). However, the incidences of smoking and drinking both trended downward (P < 0.05). The levels of total cholesterol and triglycerides also showed a downward trend (P < 0.05), as did levels of low-density lipoprotein, but not to the point of statistical significance (P > 0.05). Mortality during hospitalization decreased significantly from 2010 to 2014 (P < 0.05), but there was no significant improvement in the incidences of cardiac death and major adverse cardiovascular events (MACE) after 1-year follow-up (P > 0.05).

Conclusions: Over the 5 years studied, the overall incidence of cardiac death and MACE for young CHD patients (≤45 years) has shown little improvement. Secondary prevention of young CHD, and its risk factors, as well as appropriate courses of medical treatment must be further elucidated.

Keywords: Coronary heart disease; Prevention; Prognosis; Risk factors; Young.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Age of Onset
  • Alcohol Drinking / adverse effects
  • Alcohol Drinking / epidemiology
  • China / epidemiology
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / epidemiology*
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / therapy
  • Diabetes Mellitus / epidemiology
  • Female
  • Hospitalization
  • Humans
  • Hyperlipidemias / epidemiology
  • Hypertension / epidemiology
  • Incidence
  • Male
  • Prognosis
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Sex Distribution
  • Smoking / adverse effects
  • Smoking / epidemiology
  • Time Factors