Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia

Leuk Res. 2017 Mar;54:1-6. doi: 10.1016/j.leukres.2016.12.005. Epub 2016 Dec 26.

Abstract

Cell signalling, which is often derailed in cancer, is a network of multiple interconnected pathways with numerous feedback mechanisms. Dynamics of cell signalling is intimately regulated by addition and removal of phosphate groups by kinases and phosphatases. We examined expression of members of the PTP4A family of phosphatases across acute leukemias. While expression of PTP4A1 and PTP4A2 remained relatively unchanged across diseases, PTP4A3 showed marked overexpression in ETV6-RUNX1 and BCR-ABL1 subtypes of precursor B cell acute lymphoblastic leukemia. We show that PTP4A3 is regulated by the ETV6-RUNX1 fusion, but noticed no marked impact on cell viability either after PTP4A3 silencing or treatment with a PTP4A3 inhibitor. Regulation of PTP4A3 expression is altered in specific subgroups of acute leukemias and this is likely brought about by expression of the aberrant fusion genes.

Keywords: ETV6-RUNX1; Leukemia; PTP4A3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Survival
  • Core Binding Factor Alpha 2 Subunit*
  • Fusion Proteins, bcr-abl
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasm Proteins / genetics*
  • Oncogene Proteins, Fusion*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Protein Tyrosine Phosphatases / genetics*

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • TEL-AML1 fusion protein
  • Fusion Proteins, bcr-abl
  • PTP4A3 protein, human
  • Protein Tyrosine Phosphatases