Endoplasmic reticulum-mitochondria Ca 2+ crosstalk in the control of the tumor cell fate

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):858-864. doi: 10.1016/j.bbamcr.2016.12.024. Epub 2017 Jan 4.

Abstract

Mitochondria-associated membranes are juxtaposed between the endoplasmic reticulum and mitochondria and have been identified as a critical hub in the regulation of apoptosis and tumor growth. One key function of mitochondria-associated membranes is to provide asylum to a number of proteins with tumor suppressor and oncogenic properties. In this review, we discuss how Ca2+ flux manipulation represents the primary mechanism underlying the action of several oncogenes and tumor-suppressor genes and how these networks might be manipulated to provide novel therapies for cancer. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Carcinogenesis
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Ion Transport
  • Mitochondria / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology

Substances

  • Calcium