[Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze]

Farmakol Toksikol. Jul-Aug 1989;52(4):14-7.
[Article in Russian]

Abstract

During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Learning / drug effects*
  • Male
  • Memory / drug effects
  • Memory, Short-Term / drug effects
  • Piracetam / pharmacology*
  • Pyrrolidinones / pharmacology*
  • Rats
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Pyrrolidinones
  • nicotinoyl-GABA
  • gamma-Aminobutyric Acid
  • Piracetam