Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

doi:10.3389/fnins.2016.00578

Comment

. 2016 Dec 23:10:578.

doi: 10.3389/fnins.2016.00578. eCollection 2016.

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

Hugo J R Fernandes¹, Brent J Ryan², Richard Wade-Martins²

Affiliations

¹ Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham Birmingham, UK.
² Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford Oxford, UK.

PMID: 28066164
PMCID: PMC5179548
DOI: 10.3389/fnins.2016.00578

Free PMC article

Comment

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

Hugo J R Fernandes et al. Front Neurosci. 2016.

Free PMC article

. 2016 Dec 23:10:578.

doi: 10.3389/fnins.2016.00578. eCollection 2016.

Authors

Hugo J R Fernandes¹, Brent J Ryan², Richard Wade-Martins²

Affiliations

¹ Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham Birmingham, UK.
² Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford Oxford, UK.

PMID: 28066164
PMCID: PMC5179548
DOI: 10.3389/fnins.2016.00578

No abstract available

Keywords: Drosophila; ER stress; ER stress response; GBA; Parkinson's disease; chaperones; dopaminergic neurons; therapeutics.

PubMed Disclaimer

Comment on

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.
Sanchez-Martinez A, Beavan M, Gegg ME, Chau KY, Whitworth AJ, Schapira AH. Sanchez-Martinez A, et al. Sci Rep. 2016 Aug 19;6:31380. doi: 10.1038/srep31380. Sci Rep. 2016. PMID: 27539639 Free PMC article.

Cited by

Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.
Jiang Z, Huang Y, Zhang P, Han C, Lu Y, Mo Z, Zhang Z, Li X, Zhao S, Cai F, Huang L, Chen C, Shi Z, Zhang Y, Ling F. Jiang Z, et al. Mol Brain. 2020 Jul 8;13(1):102. doi: 10.1186/s13041-020-00637-x. Mol Brain. 2020. PMID: 32641146 Free PMC article.
Glucocerebrosidase and its relevance to Parkinson disease.
Do J, McKinney C, Sharma P, Sidransky E. Do J, et al. Mol Neurodegener. 2019 Aug 29;14(1):36. doi: 10.1186/s13024-019-0336-2. Mol Neurodegener. 2019. PMID: 31464647 Free PMC article. Review.
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R. Zambon F, et al. Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038. Hum Mol Genet. 2019. PMID: 30753527 Free PMC article.

References

1. Celardo I., Costa A. C., Lehmann S., Jones C., Wood N., Mencacci N. E., et al. . (2016). Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease. Cell Death Dis. 7, E2271. 10.1038/cddis.2016.173 - DOI - PMC - PubMed
1. Chung C. Y., Khurana V., Auluck P. K., Tardiff D. F., Mazzulli J. R., Soldner F., et al. . (2013). Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 342, 983–987. 10.1126/science.1245296 - DOI - PMC - PubMed
1. Colla E., Coune P., Liu Y., Pletnikova O., Troncoso J. C., Iwatsubo T., et al. . (2012). Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J. Neurosci. 32, 3306–3320. 10.1523/JNEUROSCI.5367-11.2012 - DOI - PMC - PubMed
1. Cooper A. A., Gitler A. D., Cashikar A., Haynes C. M., Hill K. J., Bhullar B., et al. . (2006). Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324–328. 10.1126/science.1129462 - DOI - PMC - PubMed
1. Credle J. J., Forcelli P. A., Delannoy M., Oaks A. W., Permaul E., Berry D. L., et al. . (2015). α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol. Dis. 76, 112–125. 10.1016/j.nbd.2015.02.005 - DOI - PubMed

Publication types

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Molecular Biology Databases
- FlyBase

[1] Celardo I., Costa A. C., Lehmann S., Jones C., Wood N., Mencacci N. E., et al. . (2016). Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease. Cell Death Dis. 7, E2271. 10.1038/cddis.2016.173 - DOI - PMC - PubMed

[2] Celardo I., Costa A. C., Lehmann S., Jones C., Wood N., Mencacci N. E., et al. . (2016). Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease. Cell Death Dis. 7, E2271. 10.1038/cddis.2016.173 - DOI - PMC - PubMed

[3] Chung C. Y., Khurana V., Auluck P. K., Tardiff D. F., Mazzulli J. R., Soldner F., et al. . (2013). Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 342, 983–987. 10.1126/science.1245296 - DOI - PMC - PubMed

[4] Chung C. Y., Khurana V., Auluck P. K., Tardiff D. F., Mazzulli J. R., Soldner F., et al. . (2013). Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 342, 983–987. 10.1126/science.1245296 - DOI - PMC - PubMed

[5] Colla E., Coune P., Liu Y., Pletnikova O., Troncoso J. C., Iwatsubo T., et al. . (2012). Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J. Neurosci. 32, 3306–3320. 10.1523/JNEUROSCI.5367-11.2012 - DOI - PMC - PubMed

[6] Colla E., Coune P., Liu Y., Pletnikova O., Troncoso J. C., Iwatsubo T., et al. . (2012). Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J. Neurosci. 32, 3306–3320. 10.1523/JNEUROSCI.5367-11.2012 - DOI - PMC - PubMed

[7] Cooper A. A., Gitler A. D., Cashikar A., Haynes C. M., Hill K. J., Bhullar B., et al. . (2006). Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324–328. 10.1126/science.1129462 - DOI - PMC - PubMed

[8] Cooper A. A., Gitler A. D., Cashikar A., Haynes C. M., Hill K. J., Bhullar B., et al. . (2006). Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324–328. 10.1126/science.1129462 - DOI - PMC - PubMed

[9] Credle J. J., Forcelli P. A., Delannoy M., Oaks A. W., Permaul E., Berry D. L., et al. . (2015). α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol. Dis. 76, 112–125. 10.1016/j.nbd.2015.02.005 - DOI - PubMed

[10] Credle J. J., Forcelli P. A., Delannoy M., Oaks A. W., Permaul E., Berry D. L., et al. . (2015). α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol. Dis. 76, 112–125. 10.1016/j.nbd.2015.02.005 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

Affiliations

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

Authors

Affiliations

Comment on

Similar articles

Cited by

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases