Sumoylation in Lens Differentiation and Pathogenesis

Abstract

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Keywords: Lens; cataractogenesis; differentiation; pathogenesis; sumoylation.