The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity

Chem Commun (Camb). 2017 Jan 19;53(7):1289-1292. doi: 10.1039/c6cc07803f.

Abstract

By combining KLVFF peptide and self-assembly chaperone we fabricate a new system to achieve the synchronization between Aβ fibril disaggregation and reducing toxicity of Aβ fragments (monomers or oligomers) that consequently formed. When the KLVFF peptides disaggregate fibrils into fragments, the hydrophobic domains of self-assembly chaperones promptly bind them at the same time. This binding blocks the re-aggregation of the fragments and their interaction with cells, and hence reduces the toxicity of these dangerous fragments.

MeSH terms

  • Amyloid / chemistry*
  • Amyloid / metabolism*
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / toxicity*
  • Drug Synergism
  • Hydrophobic and Hydrophilic Interactions
  • Micelles
  • Molecular Chaperones / chemical synthesis
  • Molecular Chaperones / chemistry
  • Molecular Chaperones / pharmacology*
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Particle Size
  • Protein Aggregates / drug effects
  • Protein Aggregation, Pathological / drug therapy*
  • Surface Properties

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Micelles
  • Molecular Chaperones
  • Oligopeptides
  • Protein Aggregates