A Self-Powered Implantable Drug-Delivery System Using Biokinetic Energy

Peiyi Song; Shuangyang Kuang; Nishtha Panwar; Guang Yang; Danny Jian Hang Tng; Swee Chuan Tjin; Wun Jern Ng; Maszenan Bin Abdul Majid; Guang Zhu; Ken-Tye Yong; Zhong Lin Wang

doi:10.1002/adma.201605668

A Self-Powered Implantable Drug-Delivery System Using Biokinetic Energy

Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201605668. Epub 2017 Jan 9.

Authors

Peiyi Song^{1

2}, Shuangyang Kuang³, Nishtha Panwar², Guang Yang², Danny Jian Hang Tng⁴, Swee Chuan Tjin^{1

2}, Wun Jern Ng¹, Maszenan Bin Abdul Majid¹, Guang Zhu³, Ken-Tye Yong^{1

2}, Zhong Lin Wang^{3

5}

Affiliations

¹ Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One #06-08, Singapore, 637141, Singapore.
² School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
³ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
⁴ Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
⁵ School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0245, USA.

PMID: 28067957
DOI: 10.1002/adma.201605668

Abstract

The first triboelectric-nanogenerator (TENG)-based self-powered implantable drug-delivery system is presented. Pumping flow rates from 5.3 to 40 µL min^-1 under different rotating speeds of the TENG are realized. The implantable drug-delivery system can be powered with a TENG device rotated by human hand motion. Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by utilizing the biokinetic energies of human hands.

Keywords: biokinetic energy; electrochemical pressure pumping; implantable drug-delivery systems (iDDSs); self-powered; triboelectric nanogenerators (TENGs).