Modeling white matter microstructure

Funct Neurol. Oct/Dec 2016;31(4):217-228. doi: 10.11138/fneur/2016.31.4.217.

Abstract

Quantitative magnetic resonance imaging can be combined with advanced biophysical models to measure microstructural features of white matter. Non-invasive microstructural imaging has the potential to revolutionize neuroscience, and acquiring these measures in clinically feasible times would greatly improve patient monitoring and clinical studies of drug efficacy. However, a good understanding of microstructural imaging techniques is essential to set realistic expectations and to prevent over-interpretation of results. This review explains the methodology behind microstructural modeling and imaging, and gives an overview of the breakthroughs and challenges associated with it.

Publication types

  • Review

MeSH terms

  • Brain / anatomy & histology
  • Brain / diagnostic imaging*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Models, Neurological*
  • White Matter / anatomy & histology
  • White Matter / diagnostic imaging*