1 Inserm UMR1027, Toulouse, France, University of Toulouse III, UMR1027, Toulouse, France, Centre Hospitalier Universitaire de Toulouse, Department of Epidemiology, Toulouse, France, benoit.lepage@univ-tlse3.fr University of Toulouse III, UMR1027, Toulouse, France, Toulouse Institute of Mathematics, UMR 5219, Toulouse, France Inserm UMR1027, Toulouse, France, University of Toulouse III, UMR1027, Toulouse, France, Centre Hospitalier Universitaire de Toulouse, Department of Epidemiology, Toulouse, France.