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. 2017 May;70(5):601-606.
doi: 10.1038/ja.2016.158. Epub 2017 Jan 11.

Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490

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Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490

Yixizhuoma et al. J Antibiot (Tokyo). 2017 May.

Abstract

Chemical investigations of the ethyl acetate extract of Streptomyces sp. IFM 11490 have led to the isolation of six new angucycline metabolites, named elmenols C-H (1-6), along with the previously reported elmonin (7) and elmenols A (8) and B (9). The known LS1924A (10), 6-deoxy-8-methylrabelomycin (11), tetrangulol methyl ether (12) and angucyclinone (13) were additionally identified. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. Compounds 1-6 were evaluated for their abilities to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma (AGS) cells. Compounds 5 (10 μm) and 6 (50 μm) in combination with TRAIL showed moderate activity in sensitizing TRAIL-resistant AGS cells.

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