Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate

Infect Immun. 1989 Nov;57(11):3666-9. doi: 10.1128/iai.57.11.3666-3669.1989.

Abstract

The Anaplasma marginale surface protein complex MSP-1 of the Florida isolate is composed of a 105-kilodalton (kDa) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kDa polypeptide. Antigenically similar polypeptides in the Okanogan, Wash. (Washington-O), isolate MSP-1 are 86 and 100 kDa, respectively. Immunization of cattle with Florida isolate MSP-1 induced antibody titers to both MSP-1 polypeptides and protected cattle against homologous and heterologous challenge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anaplasma / immunology*
  • Anaplasmosis / prevention & control*
  • Animals
  • Antigens, Bacterial / administration & dosage*
  • Antigens, Surface / administration & dosage
  • Bacterial Proteins / immunology*
  • Cattle
  • Cattle Diseases / prevention & control*
  • Molecular Weight
  • Species Specificity

Substances

  • Antigens, Bacterial
  • Antigens, Surface
  • Bacterial Proteins