Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats

Acta Cir Bras. 2016 Dec;31(12):826-833. doi: 10.1590/S0102-865020160120000008.


Purpose:: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats.

Methods:: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams.

Results:: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments.

Conclusions:: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.

MeSH terms

  • Animals
  • Cacao
  • Cocos / chemistry*
  • Disease Models, Animal
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Kidney / drug effects
  • Liver / drug effects
  • Lung / drug effects
  • Rats
  • Rats, Wistar
  • Resuscitation / methods
  • Sepsis / drug therapy*
  • Shock, Hemorrhagic / drug therapy*
  • Simvastatin / administration & dosage*
  • Sodium Chloride / administration & dosage
  • Water*


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Water
  • Sodium Chloride
  • Simvastatin