Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.
Keywords: GPCR; THC; axonal growth; bioenergetics; cannabinoid; cannabinoid receptor 1; cannabis; endocannabinoid; mitochondrial import; respiration.
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