(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity

Cell Metab. 2017 Jan 10;25(1):8-10. doi: 10.1016/j.cmet.2016.12.020.


Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.

Keywords: GPCR; THC; axonal growth; bioenergetics; cannabinoid; cannabinoid receptor 1; cannabis; endocannabinoid; mitochondrial import; respiration.

Publication types

  • Comment

MeSH terms

  • Cannabinoids*
  • Humans
  • Memory
  • Mitochondria*
  • Receptor, Cannabinoid, CB1
  • Receptors, Cannabinoid
  • Signal Transduction


  • Cannabinoids
  • Receptor, Cannabinoid, CB1
  • Receptors, Cannabinoid